Fig. 9.

Literature-pruned subset of larger data-driven microRNA regulatory network depicted previously captures the interactions relevant to well-established SHR literature focusing on angiotensin II and inflammatory signaling. The network relates key microRNAs either persistently upregulated or showing a larger rise in SHR than in WKY during the developmental phase of hypertension. A common feature of this network is that the 2 key microRNAs are predicted by a consensus of bioinformatics tools to target negative regulators of pathways that are amplified in SHR during the development of hypertension.