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. 2015 Jun 25;309(5):G387–G399. doi: 10.1152/ajpgi.00460.2014

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Fig. 10. — Schematic diagram of proposed roles of SCP-2/SCP-x and impact of SCP-2/SCP-x gene ablation on cholesterol transport and metabolism in C57BL/6Ncr mice. Pathway or product decreased due loss of SCP-2 or SCP-x (downward facing arrow), due to product increase (upward facing arrow), and loss of cholesterol transport protein activity in cellular pathway (cross). ABCG5, ATP-binding cassette transporter G5; ABCG8, ATP-binding cassette transporter G8; Acc 1, acetyl CoA carboxylase-1; Acc2, acetyl CoA carboxylase-2; BSEP, bile salt export pump; C, free cholesterol; CE, cholesteryl ester; CEH, cholesterol ester hydrolase; CYP27A1, cholesterol-27α-hydroxylase; ER, endoplasmic reticulum; Fas, fatty acid synthetase; Hm*gcs, hydroxymethylglutaryl CoA synthase; Hmgcr, hydroxymethylglutaryl CoA reductase; INSIG, insulin-induced gene protein; LDL-R, low density lipoprotein receptor; NTCP, Na+-taurocholate cotransporting polypeptide; OATP2, organic anion transporting polypeptide 2; P, phospholipid; SCAP, SREBP cleavage activating protein; SR-B1, scavenger receptor B1; TG, triacylglycerol.