Table 3.

Effect of SCP-2/SCP-x gene ablation, high-cholesterol diet, and both together on serum lipids

	Male				Female
	WT		DKO		WT		DKO
	CO	CH	CO	CH	CO	CH	CO	CH
Total protein, mg/dl	1,260 ± 30	1,140 ± 60	1,110 ± 30	1,130 ± 40	1,190 ± 80	1,080 ± 90	1,190 ± 110	1,080 ± 60
Total lipid, mg/dl	262 ± 7	222 ± 8†	260 ± 10	215 ± 5†	153 ± 5	144 ± 4	158 ± 9	152 ± 6
Neutral lipid, mg/dl	160 ± 7	143 ± 6	157 ± 9	124 ± 4†	89 ± 3	94 ± 4	98 ± 6	91 ± 6
Phospholipid, mg/dl	99 ± 3	77 ± 4†	98 ± 6	87 ± 3	62 ± 3	48 ± 3†	59 ± 3	58 ± 3*
Serum polar/neutral lipid, mg/mg	0.65 ± 0.04	0.56 ± 0.03	0.65 ± 0.04	0.74 ± 0.03*	0.73 ± 0.04	0.53 ± 0.04†	0.63 ± 0.02	0.69 ± 0.06
Liver polar/neutral lipid, mg/mg	1.5 ± 0.1	1.1 ± 0.1†	1.1 ± 0.1*	0.9 ± 0.1	1.3 ± 0.2	0.5 ± 0.1†	1.3 ± 0.1	0.6 ± 0.1†

Values represent the mean ± SE; n = 6–7.

^*Genotype effect (P < 0.05 for DKO vs. WT within the same diet).

^†Diet effect (P < 0.05 for CO vs. CH diet within the same genotype).