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. 2015 Jul 9;309(5):G324–G340. doi: 10.1152/ajpgi.00108.2015

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Fig. 2. — Parkin KO mice had increased liver steatosis compared with WT mice after acute-binge, but not Gao-binge, treatment. A and B: liver triglycerides (TG) were measured for WT and Parkin KO mice after acute-binge (A) and Gao-binge (B) alcohol treatment. Data shown are means ± SE (n = 4 for controls and ≥6 for alcohol-treated mice; *P < 0.05 by 1-way ANOVA). C and D: representative hematoxylin and eosin (H&E) images from the acute-binge model (C) and the Gao-binge model (D) are shown with boxed areas enlarged. LD, lipid droplet; ×200 magnification. E and F: representative images are shown for Oil Red O staining for the acute-binge model (E) and for the Gao-binge model (F) with boxed areas enlarged (×200 magnification). G: representative electron microscopy (EM) images are shown for acute-binge-treated mice with boxed areas enlarged (bar = 500 nm; N, nucleus; M, mitochondria). H: quantification of lipid droplets per cell in acute-binge-treated mice. Data shown are means ± SE (n ≥ 10 images per mouse from 2 mice per group; *P < 0.05 by 1-way ANOVA).

Fig. 2. — Parkin KO mice had increased liver steatosis compared with WT mice after acute-binge, but not Gao-binge, treatment. A and B: liver triglycerides (TG) were measured for WT and Parkin KO mice after acute-binge (A) and Gao-binge (B) alcohol treatment. Data shown are means ± SE (n = 4 for controls and ≥6 for alcohol-treated mice; *P < 0.05 by 1-way ANOVA). C and D: representative hematoxylin and eosin (H&E) images from the acute-binge model (C) and the Gao-binge model (D) are shown with boxed areas enlarged. LD, lipid droplet; ×200 magnification. E and F: representative images are shown for Oil Red O staining for the acute-binge model (E) and for the Gao-binge model (F) with boxed areas enlarged (×200 magnification). G: representative electron microscopy (EM) images are shown for acute-binge-treated mice with boxed areas enlarged (bar = 500 nm; N, nucleus; M, mitochondria). H: quantification of lipid droplets per cell in acute-binge-treated mice. Data shown are means ± SE (n ≥ 10 images per mouse from 2 mice per group; *P < 0.05 by 1-way ANOVA).