Fig. 8.

Lipid peroxidation was increased in Parkin KO mice compared with WT mice after alcohol treatment. A–D: WT and Parkin KO mice were treated with alcohol by using the acute-binge (A and B) or Gao-binge (C and D) model. Representative images are shown from 4-hydroxynonenal (4HNE) immunohistochemistry after acute-binge (A) or Gao-binge (C) treatment, and data are represented as the percent (%) of positively stained areas compared with the total liver area [B (acute), D (Gao-Binge)]. Results shown are means ± SE (n ≥ 3 mice per group; *P < 0.05 compared with WT control by 1-way ANOVA).