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. 2015 Sep 2;5:13628. doi: 10.1038/srep13628

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Copyright © 2015, Macmillan Publishers Limited

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(a) T₂*-weighted images of immune-deficient and immune-competent mouse brains, indicating the site of cell delivery () and cell migration to the radiation-induced lesion (). (b) Black-pixel analyses of T₂*-weighted images of mouse brains from both groups at the middle and end of week one, indicating significant cell migration to the radiation-induced lesion site (n = 5; P < 0.0088 and P < 0.009, respectively). (c) Three-dimensional reconstruction of T₂*-weighted MR images of brains from immune-deficient and immune-competent mice, indicate cell distribution at both the implantation and radiation-induced lesion sites. () represents the dual magnetically labelled cells lodged at the implantation site. () represents the migrated dual magnetically labelled cells at the radiation-induced lesion sites. (d) Histology of adjacent slices of a representative immune-deficient mouse brain indicates the migration of iron-containing cells from the implantation site to the lesion site through the corpus callosum. () represents the dual magnetically labelled cells lodged at the implantation site. () represents migrating dual magnetically labelled cells. (e) Perl’s Prussian blue staining of stem cell implantation tracts of both immune-deficient and immune-competent mice. () implanted cells, and () infiltrating cells.

Inline graphic — (a) T₂*-weighted images of immune-deficient and immune-competent mouse brains, indicating the site of cell delivery () and cell migration to the radiation-induced lesion (). (b) Black-pixel analyses of T₂*-weighted images of mouse brains from both groups at the middle and end of week one, indicating significant cell migration to the radiation-induced lesion site (n = 5; P < 0.0088 and P < 0.009, respectively). (c) Three-dimensional reconstruction of T₂*-weighted MR images of brains from immune-deficient and immune-competent mice, indicate cell distribution at both the implantation and radiation-induced lesion sites. () represents the dual magnetically labelled cells lodged at the implantation site. () represents the migrated dual magnetically labelled cells at the radiation-induced lesion sites. (d) Histology of adjacent slices of a representative immune-deficient mouse brain indicates the migration of iron-containing cells from the implantation site to the lesion site through the corpus callosum. () represents the dual magnetically labelled cells lodged at the implantation site. () represents migrating dual magnetically labelled cells. (e) Perl’s Prussian blue staining of stem cell implantation tracts of both immune-deficient and immune-competent mice. () implanted cells, and () infiltrating cells.