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. 2015 Aug;149(2):481–492.e7. doi: 10.1053/j.gastro.2015.04.015

Figure 7.

Figure 7

CM_128 markedly reduces pancreatic histopathology in TLCS-AP and FAEE-AP. Both models resulted in substantial increases in (A) edema, (B) inflammation, (C) necrosis, and (D) total histology score. Intraperitoneal administration of CM_128 at 20 mg/kg given at 1 hour after disease induction (early) and 6 hours after (late) significantly reduced all parameters, with a more marked reduction when CM_128 was administered early (mean ± SEM ≥6 mice/group; *P < .05, control vs 2 models; †P < .05 TLCS-AP vs TLCS-AP plus CM_128; ‡P < .05, FAEE-AP vs FAEE-AP plus CM_128; and §P < .05, CM_128 early vs late). (E) Representative images showing normal pancreatic histology, typical histopathology from 2 models, and typical histopathology from 2 models after treatment with CM_128 early and late after disease induction (H&E; scale bar: 50 μm).