Supplementary Figure 3.

CM_128 administered from 6 hours after disease induction (late) markedly reduced biochemical responses in TLCS-AP and FAEE-AP. Two models at 6 and 24 hours resulted in substantial increase of (A) serum amylase, (B) IL6, (C) pancreatic trypsin activity, (D) pancreatic activity, and (E) lung MPO activity, with more marked increase of IL6 and lung MPO activity at 6 hours, but of pancreatic trypsin and MPO activity at 24 hours. Intraperitoneal administration of CM_128 at 20 mg/kg late significantly reduced all parameters from levels at 6 hours (mean ± SEM ≥6 mice/group; *P < .05, control vs 2 models at 6 h; ^†P < .05 2 models at 6 vs 24 h; ^‡P < .05, TLCS-AP at 6 h vs TLCS-AP plus CM_128; ^§P < .05, FAEE-AP at 6 h vs FAEE-AP plus CM_128).