Supplementary Figure 4.

CM_128 administered from 6 hours after disease induction (late) markedly reduced pancreatic histopathology in TLCS-AP and FAEE-AP. Two models at 6 and 24 hours resulted in substantially progressive increases in (A) edema, (B) inflammation, (C) necrosis, and (D) total histology score, with more marked increase of all scores at 24 hours. Intraperitoneal administration of CM_128 at 20 mg/kg from 6 hours after disease induction significantly reduced edema, but not inflammation, necrosis, or total histology scores at 6 hours (mean ± SEM ≥6 mice/group; *P < .05, control vs 2 models at 6 hours; ^†P < .05 2 models at 6 vs 24 hours; ^‡P < .05, TLCS-AP at 6 h vs TLCS-AP plus CM_128; ^§P < .05, FAEE-AP at 6 h vs FAEE-AP plus CM_128). (E) Representative images showing normal pancreatic histology, typical histopathology from 2 models at 6 and 24 hours, and typical histopathology from 2 models after treatment with CM_128 administered late after disease induction (H&E; scale bar: 50 μm).