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. 2015 Sep 2;5:13691. doi: 10.1038/srep13691

Figure 3. CpG methylation of H19 Imprinted Controlled region following reprogramming and differentiation.

Figure 3

Bisulfite sequencing of H19 ICR revealed that CpG methylation was almost completely erased following reprogramming of (A) SSCiPSC (68% in SSC vs 0–2% in SSCiPSC) in comparison to (B) fiPSC (48% in fibroblast vs 20–39.3% in fiPSC). (C) The loss of imprinting erasure in SSCiPSC is maintained even following differentiation.