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. 2015 Sep 2;5:13691. doi: 10.1038/srep13691

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(A) CRISPR/Cas mediated knockout of endogenous Tet1 and Tet2 loci by intra-cytoplasmic injection of in vitro transcribed Cas9 mRNA and sgRNA into mouse 2-cells embryos. CRISPR injection resulted in indels and two different genotypes. The CRISPR target sequence is indicated in green letters, whereas red letters indicates the indels generated. (B) Methylation at H19 ICR following reprogramming of Tet1 and Tet2 knockout SSC into three different lines of SSCiPSC.