Table 1.
Overview of the effects of marine natural compounds on STAT family proteins.
| N | Compound(s) | Disease model | Cell lines | Effect observed | STAT protein | Reference |
|---|---|---|---|---|---|---|
| 1 | Cytarabine (Ara-C) | Leukemia | K562 | Inhibition of STAT5 tyrosine phosphorylation | STAT5 | [26] |
| 15 | DMXBA (GTS-21) | Preadipocyte | 3T3-L1 | Reduction ASP-mediated chemokine MCP-1 secretion | STAT3 | [38] |
| 19 | Bryostatin 1 | Blood cancer | Chronic lymphocytic leukemia isolates cells | Induction of tyrosine phosphorylation, DNA binding of STAT1 | STAT1 | [70] |
| 22 | (1S,2S,3E,7E,11E)-3,7,11,15-Cembratetraen-17,2-olide (LS-1) | Colon cancer | HT-29 | Disruption of mitochondrial membrane potential, ROS generation, Cell cycle arrest, De-phosphorylation of STAT3 | STAT3 | [71] |
| 23 | Sarcodiol (SD) | Skin cancer | B16F10 | Inhibition of de novo DNA Synthesis, Induction of DNA fragmentation, Inhibition of STAT3 | STAT3 | [72] |
| 24 | Apratoxin A | Osteosarcoma, Breast cancer | U2OS, MCF7 | Inhibition of STAT3 tyrosine phosphorylation. Gp130 degradation | STAT3 | [73] |
| 25 | GV-c9, and GV-c10 | Macrophage | Raw 264.7 | Inhibition of inflammatory markers (IL-6, TNF-alpha, and nitric oxide) | STAT1 | [74] |