Schematic representation of the MEP pathway and the carotenoid biosynthetic pathway in P. tricornutum. Modified from Bertrand [38], Coesel et al. [39], Dambek et al. [40], Hemmerlin [41], Lohr et al. [42], Mikami and Hosokawa [43] and Vranová et al. [44]. DXS: 1-deoxy-d-xylulose 5-phosphate synthase; DXR: 1-deoxy-d-xylulose 5-phosphate reductoisomerase; MCT: 2C-methyl-d-erythritol 4-phosphate cytidyltransferase; CMK: 4-diphosphocytidyl-2C-methyl-d-erythritol kinase; MDS: 2C-methyl-d-erythritol 2,4-cyclodiphosphate synthase; HDS: 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; HDR: 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase; IDI: isopentenyl diphosphate:dimethylallyl diphosphate isomerase; GGDS: geranylgeranyl diphosphate synthase; PSY: phytoene synthase; PDS: phytoene desaturase; ZDS: ζ-carotene desaturase; CRTISO: carotenoid isomerase; LCYB: lycopene β-cyclase; LUT-like: lutein deficient-like; ZEP: zeaxanthin epoxidase; VDE: violaxanthin de-epoxidase; VDL: violaxanthin de-epoxidase-like; NXS: neoxanthin synthase.