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. 2015 Jun 26;54(31):8896–8927. doi: 10.1002/anie.201412070

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© 2015 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

© 2015 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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β-Sheet mimetics: Turn mimetics: l-Pro-d-Pro (6), dibenzofuran derivatives (7), oligourea (8), azobenzene (9); Macrocyclization: head to tail (10), side chain to side chain cross-link with a disulfide (11) and 1,2,3-triazole ring (12), side chain to side chain π–π interaction (Trp–Trp; 13) and cation–π interaction (N^δ-trimethylornithine–Trp; 14); β-strand-enforcing amino acids: 1,6-dihydro-3(2H)-pyridinone (Ach, 15), Hao building block (16), diphenylacetylene building block (17); Structural mimetics: piperidine–piperidinone-based strand mimetic (18); class A/B: yellow; class C: blue. Box: structure used in the context of PPI inhibition.