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. 2015 Jun 26;54(31):8896–8927. doi: 10.1002/anie.201412070

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© 2015 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

© 2015 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Chemical structures of covalently constrained structural α-helix mimetics: An oligooxopiperazine (37) and a spiroligomer (38). The substituents highlighted in gray are designed to mimic the i, i+3/4, and i+7 side chains of an α-helix.