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. 2015 Jun 26;54(31):8896–8927. doi: 10.1002/anie.201412070

Figure 19.

Figure 19

Six-helix bundle of gp-41 CHR and NHR helices: a) Crystal structure of the six-helix bundle involving three CHR (blue) and three NHR (orange) helixes (PDB 1AIK).[432] b) Two examples of lactam-bridged stabilized CHR-derived α-helices: HIV 31[434] and C14Linkmid including superimposed crystal structures of a CHR fragment (blue, PDB 1AIK) and C14Linkmid (gray, PDB 1GZL).[216] The amide cross-link is highlighted in red. c) Sequence of CHR-derived double-stapled peptide SAH-gp41.[232] d) Chimeric peptide α-α/β-8 derived from a mutant CHR form (mtCHR). Superimposed crystal structures of mtCHR (blue, PDB 3F4Y) and α-α/β-8 (gray, PDB 3G7A).[439] β-Amino acids are highlighted in red (X=ACPC, Z=APC, βE=β3-glutamate). e) CHR-derived terphenyl structural mimetic[280] (side chains of amino acids in boxes are shown explicitly in the crystal structures).