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. 2015 Sep 2;5:13713. doi: 10.1038/srep13713

Figure 1. GRA reduces CNS inflammation and myelin damage in EAE.

Figure 1

(a) Chemical structure of GRA. (b,c) Clinical scores of EAE mice that were i.p. injected daily with GRA (75 mg/kg) or vehicle control from day 7 (n = 10, preventive treatment) or day 11 (n = 7, therapeutic treatment)-post immunization onwards. (d) Transverse sections of spinal cords from control EAE mice and GRA-treated mice were stained with H&E or Luxol fast blue (×40). (e) Histopathology score of CNS inflammation and demyelination was quantified using H&E and Loxol fast blue staining on day 20 post immunization. (f) TEM images showed demyelinated axons in the spinal cords of control EAE and GRA-treated mice on day 25. Data are representative of three independent experiments. *P < 0.05.