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The expression pattern of Prnp overlaps with immune-privileged organs and extends into the lymphoreticular system. Schematic representation of (A) major immune-privileged organs; highlighting the brain, testes, pregnant uterus, and eye, and (B) the organs with highest levels of PrPC overlap with the immune-privileged organs with the addition of lymphoreticular tissues, illustrated with lymph nodes and the spleen.
