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. 2015 Sep 2;5:13748. doi: 10.1038/srep13748

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Copyright © 2015, Macmillan Publishers Limited

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(A) Circulating platelets in kanamycin-treated (5, and 50 mg/day) and kanamycin plus LPS-treated (0.1, 1.0, 10.0, 100.0 and 1000.0 μg/100 g/day) mice for 10 d. Platelet counts with LPS IP (0.1, 1.0 and 10.0 μg/100 g/day) were significantly increased compared with the control (P < 0.05) in a dose-dependent manner. (B) The respective time curve represents the mice recorded at 3, 6, and 24 h and 7 d after the termination of treatments. Platelet counts slightly decreased after 7 d of kanamycin injection. The IP injection of LPS restored the platelet numbers after 7 d in kanamycin-pretreated mice. In contrast, LPS reduced the circulating platelet count in 24 h.