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. 2015 Sep 2;5:13748. doi: 10.1038/srep13748

Figure 8. Effect of LPS or IL-6 alone or in combination on platelet counts.

Figure 8

(A) Normal mice received IL-6 or IL-6 plus LPS at the indicated dosage once per day for 7 consecutive days. The control mice received PBS-BSA only. Platelets were counted at the indicated time points. Each dose resulted in significant increases in the platelet counts relative to the control (*P < 0.05; **P < 0.01, and ***P < 0.001). (B) Platelet counts in 5-FU-induced myelosuppressed mice. One hour after 5-FU injection at a dose of 150 mg/kg, the mice were intravenously given PBS-BSA (open circles), 8.0 μg/kg/day LPS (filled squares), 100 μg/kg/day IL-6 (open squares), or a combination of LPS and IL-6 (filled triangles). Mice untreated with 5-FU but still given PBS-BSA injections were used to gauge the baseline platelet levels (open triangles). Platelets were counted at the indicated time points.