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. 2015 Aug 14;6:7998. doi: 10.1038/ncomms8998

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(a,b) Mid-stage 12 embryos with 48Y-Gal4 driving expression of either Bbow alone (a) or together with Baz-GFP (b). Arrows point to the migration front of PMG cells. (c–e) E-Cad levels are higher throughout the PMG on Baz overexpression (d) and markedly decreased in baz mutants, which also shows a strong delay in migration. (e–h) Ectopic Baz-GFP recruits endogenous E-Cad which co-localize in punctae ((g) compare with wild type (WT) (f)), in contrast endogenous Baz does not co-localize with overexpressed E-Cad-GFP (h). (i) Illustration of the regulation of E-Cad levels at the membrane through interactions with Baz and the endocytic pathway in both PMECs (black) and ICPs (red); and of the trafficking of integrins mediating dynamic interactions between the PMECs and the mesoderm cells (grey). Scale bar, 20 μm.