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A–C, Overview of experimental design for in vivo dual-selectin–targeted US in pigs shows, A, the testing of different MB doses, B, the testing for reproducibility, and, C, the correlation of imaging findings with pathologic findings. MBControl = control MBs, MBSelectin = dual-selectin–targeted MBs, TNBS = 2, 4, 6-trinitrobenzene sulfonic acid. (For more details on the animal model, please see Appendix E1 [online].)
