Figure 2b:
(a) Graph summarizes quantitative US signal intensities (represented as signal intensity ratios) observed in five pigs with acute terminal ileitis with increasing doses (0.5, 1.0, 2.5, 5.0, 10, and 20 × 108/kg) of dual-selectin–targeted contrast MBs (MBSelectin). Error bars = standard deviations, b.w. = body weight. (b) Representative transverse US images obtained six times in approximately the same location of an inflamed ileum segment (arrows) in one pig show increasing imaging signal (overlaid in red onto the anatomic B-mode images) with increasing MBSelectin doses, with the signal plateauing between a dose of 10 and a dose of 20 × 108/kg. Note that US with MBSelectin depicts inflammation not only in the bowel wall but also in mesenteric fat adjacent to the ileum. The different US scans were each separated by a 30-minute pause to allow contrast agent clearance.