Figure 7. Deficient IFN-λ production in RV-infected mice with elastase-induced COPD.
Mice were challenged intranasally with single-dose elastase or PBS as control. On day 10 after elastase or PBS challenge, mice were additionally challenged intranasally with RV1B or UV-inactivated RV1B (UV). (a) IFN-λ mRNA, (b) IFN-β mRNA and (c) RV RNA in lung tissue was measured by Taqman quantitative PCR. n=5 mice/group. Data were analysed by two-way ANOVA and Bonferroni post-hoc test. ***P<0.001.