Table 2. Hormones and adipokines determined in sera of control, diabetic, and HIGT-treated mice.

	Control	DM	HIGT
Insulin (pmol/l)	1,584.90 ± 302	5,97.50 ± 234*	1,850.15 ± 226
Glucagon (pmol/l)	53.93 ± 9.2	119.50 ± 19*	36.94 ± 6.7**
Leptin (pmol/l)	3,588.52 ± 282	740.77 ± 347*	2,492.73 ± 324*,**
Resistin (pg/ml)	3,482.78 ± 198	2,594.15 ± 274	3,478.99 ± 433
Adiponectin (µg/ml)	8.18 ± 0.6	7.17 ± 0.7	8.36 ± 0.9
PAI-1 (pg/ml)	2,633 ± 293	2,985 ± 590	4,654 ± 1099
IL-6 (pg/ml)	23.22 ± 5.1	16.41 ± 5.0	28.12 ± 5.3

Value of insulin in HIGT-treated mice reflects cross-reactivity in murine insulin assay. Data are presented as mean ± SD, n = 8–20 for each condition.

Con, control nondiabetic mice; DM, diabetic mice; HIGT, hepatic insulin gene therapy.

*P < 0.05 versus control; **P < 0.01 versus DM, by t-test after one-way analysis of variance with P < 0.05.