Table 2. Recent GWA S and WES studies in stroke.

First author	Study type	Phenotype	Sample size	Sample ancestry	Associated regions
Hata et al. (2011)85	GWAS	Ischaemic stroke	1 112 cases, 1 112 controls	Japanese	14q22 (PRKCH), 11q12 (AGTRL1)
Matarin et al. (2009)89	GWAS	Ischaemic stroke	249 cases, 268 controls	White	None
Gretasrdottri and Gudjartsson et al. (2008, 2009)87,88	GWAS	Ischaemic stroke	1 661 cases, 10 815 controls	Icelandic	4q25 (PITX2), 16q22.3 (ZFHX3)
Bilguvar et al. (2008)89	GWAS	lntracranial aneurysms	2 100 cases, 8 000 controls	Finish, Dutch, Japanese	2q33 (PLCL1), 8q12 (SOX17), 9p21.3 (CDKN2A, CDK N2B, ANRIL)
lkram et al. (2009)90	GWAS	Ischaemic stroke	Cohort of 19 602, 1 164 events	Caucasian	12p13.33 (NINJ2)
Yamada et al. (2009)91	GWAS	Ischaemic stroke	992 cases, 5 349 controls	Japanese	22q13 (CELSR1)
Zhang et al. (2012)92	GWAS	Ischaemic and haemorrhagic stroke	1 657 cases, 1 664 controls	Chinese	9p21.3 (ANRIL)
Matsushita et al. (2010)93	GWAS	Atherothrombotic stroke	2 775 cases, 2 839 controls	Japanese	ARHGEF 10
ISGC and WTCCC (2012)94	GWAS	Large-vessel stroke	3 548 cases, 5 972 controls	European	7p21.1 (HDAC9); replicated previous finding for cardio-embolic stroke near PITX2 and ZFHX3
Holliday et al. (2012)95	GWAS	Large-vessel stroke	1 162 cases, 1 244 controls	Australian	6p21.1
Cole et al. (2012)3	WES	Lacunar stroke	889 cases, 927 controls (10 for exome sequencing)	African American, European American	4q21.1 (CSN3) **identified by exome sequencing following previous GWAS
Zhou et al. (2014)96	GWAS	Lacunar strokes systemic vasculopathy	9 subjects (exome sequencing)	European American, European	ADA2 gene