| Saidi et al. (2007)97
|
Genotyping |
lschaemic stroke |
135 cases, 118 controls (Tunisian) |
Altered plasminogen activator inhibitor 1 (PAI-1) and
tissue-type plasminogen activator (tPA) levels: |
| Significant ↑ in PAI-1 and marked ↓ in tPA levels
correlated with 4G/5G, but not with -844G/A, PAI-1 variants |
| 4G/4G carriers had reduced risk of stroke compared with
other genotypes |
| Saidi et al. (2007)98
|
Genotyping |
lschaemic stroke |
216 cases, 282 controls (Tunisian) |
ApoE ε3 lower (0.546 vs 0.736; p < 0.001) in stroke
vs control |
| ApoE ε4 higher (0.370 vs 0.181; p < 0.001) in stroke
vs control |
| Prevalence of Apo ε4-containing phenotypes higher
in: |
| • ischaemic versus haemorrhagic (p < 0.001) |
| • small-vessel versus large-vessel stroke cases (p <
0.001) |
| • increased need for statin drugs (p = 0.040). |
| Mourad et al. (2008)105
|
Genotyping |
Sickle cell anaemia |
20 SCA cases, 10 controls (Egyptian) |
Presence or ACE D allele significantly predisposed to
stroke in children with sickle cell anaemia (SCA). |
| Saidi et al. (2008)99
|
Genotyping |
lschaemic stroke |
216 stroke patients, 318 controls (Tunisian) |
Human platelet alloantigen (HPA) – 1 a/b (p < 0.001)
and HPA-5 a/b (p < 0.001) alleles were associated with
stroke-susceptible genotypes: 1a/b-2a/a-3a/b-4a/a-5a/b protective
genotypes: 1a/a-2a/a-3a/a-4a/a-5a/a; 1a/a-2a/a-3a/b-4a/a-5a/a; 1a/b
-2a/a-3a/a-4a/a-5a/a; 1a/b-2a/a-3a/b-4a/a-5a/a) |
| Saidi et al. (2008)100
|
Genotyping |
lschaemic stroke |
329 cases, 444 controls |
Lower human platelet alloantigen, HPA-1a (p < 0.001)
and higher HPA-1b (p < 0.001) allele frequencies were seen in
cases than control subjects. |
| Homozygosity for HPA-1b (p < 0.001) alleles was more
prevalent in stroke cases than in controls. |
| Saidi et al. (2009)101
|
Genotyping |
lschaemic stroke |
228 cases, 323 controls |
Frequency of APOE ε3 allele and Apo E3/E3 genotype
lower (p < 0.001) in stroke vs controls |
| Frequency of Apo ε4 allele and genotypes (E3/E4 and
E4/E4) elevated (p < 0.001) in stroke vs controls |
| Higher proportion of Apo ε4-carrying + ACE Del/Del
positive cases seen in young (< 50 years) patients (p = 0.012)
and associated with large-vessel stroke (p = 0.035). |
| Saidi et al. (2009)102
|
Genotyping |
lschaemic stroke |
329 cases, 444 controls |
Angiotensinogen AGT 174T/235M/-6A, AGT 174T/235T/-6G.
AGT 174T/235T/- 6A and AGT 174M/235T/-6A haplotypes were
significantly associated with an increased risk of stroke. |
| Saidi et al. (2010)103
|
Genotyping |
lschaemic stroke |
329 IS patients, 444 controls |
Endothelial nitric oxide synthase (eNOS) gene
polymorphisms (298Asp allele and 298Asp/4b/-786T and 298Asp/4b/-786C
haplotypes, and in addition identified 298Asp/4a/-786T haplotypes)
were significantly associated with ischaemic stroke. |
