Table 4. Unique features of SIREN meeting the standard criteria for stroke genomics studies.

Criteria for Stroke Genomics Studies81	How met in SIREN – SIBS Genomics
Venice ‘ A’ rating for sample size	large sample size > 3000 case – control pairs
Phenomic characterization	Rigorous phenotypic assessment in patients and in controls
	Detailed investigations (min of CT) and accurate classification using OCSP, TOAST, ASCO, CCS. Data verification and Quality control System
Control for confounders	Measurement and documentation of conventional vascular risk factors to be controlled for in the analysis
External validation	External Validation in REGARDS cohort (12,500)
Others	Low genotyping error rate (Hardy-Weinberg Equilibrium will be stated in cases and controls) Genomic controls, and other methods to account for population stratification, low P value (corrected for multiple testing)