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. 2015 Sep 2;34(1):90. doi: 10.1186/s13046-015-0210-1

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© Lippolis et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Antagonism by IGF1 of Regorafenib-mediated induction of apoptosis. a. PLC/PRF/5 cell line cultured in 1 % FBS medium was treated with IGF1 40 ng/ml in combination with Regorafenib 5 μM and GSK 1 μM. The Muse Annexin V kit was used to evaluate the percentage of apoptotic cells. The means ± SD of three independent experiments is plotted in the relative graph. ***p < 0.0001. b. Representative Western blot that shows anti-apoptotic (phospho-survivin, Bcl-xL and Bcl-2) and pro-apoptotic (Bim, truncated-Bid and Bad) proteins in PLC/PRF/5 cells treated as described above