Table 3. Multivariate Logistic Regression Analysis of Hybrid Overall Response Rate.
| Univariate Model | Multivariate Modela | |||
|---|---|---|---|---|
| Factor | Odds Ratio (95% CI) | P-value | Odds Ratio (95% CI) | P-value |
| Age | 1.004 (0.967, 1.041) | 0.8353 | ||
| Male gender | 0.863 (0.376, 1.980) | 0.7279 | ||
| Rai Stage at entry:Stage III, IV | 0.265 (0.113, 0.623) | 0.0023 | 0.277 (0.108, 0.710) | 0.0075 |
| Presence of del(17p) | 0.362 (0.145, 0.902) | 0.0292 | 0.554 (0.203, 1.512) | 0.2490 |
| Presence of del(11q) | 1.017 (0.445, 2.325) | 0.9682 | ||
| Presence of bulky lymphadenopathy | 1.068 (0.493, 2.314) | 0.8679 | ||
| Baseline WBC | 0.589 (0.216, 1.609) | 0.3019 | ||
| Baseline LDH | 0.863 (0.711, 1.047) | 0.1379 | 0.895 (0.724, 1.106) | 0.3038 |
| Baseline β2-microglobulin | 0.478 (0.034, 6.672) | 0.5831 | ||
| Number of prior anti-cancer regimens | 0.843 (0.712, 0.995) | 0.0433 | 0.806 (0.655, 0.993) | 0.0427 |
| Refractory to fludarabine | 0.819 (0.153, 4.393) | 0.8161 | ||
a
A multivariate logistic regression analysis was run with all covariates for which p < 0.20 in aunivariate model. Using backward selection for covariates, low risk Rai stage and fewer prior regimens with final ORs of 0.252 (0.100, 0.636 p-value: 0.0035) and 0.813 (0.663, 0.998 p-value: 0.0483) respectively, were associated with a response.