Table 2.
Differential gene expression in sICOS-treated natural killer cells
| Gene ID | Alternate name | Accession number | Fold increase1 | P-value | Donors2 |
|---|---|---|---|---|---|
| PIM1 | NM_002648 | 2 | 8·22E-05 | 3/4 | |
| CCL1 | I309 | NM_002981 | 2·09 | 4·50E-07 | 3/4 |
| TNFRSF4 | OX40 | NM_003327 | 2·2 | 8·72E-05 | 4/4 |
| TNFRSF18 | GITR | NM_005092 | 2·51 | 1·39E-06 | 4/4 |
| Gene ID | Alternate name | Accession number | Fold decrease | P-value | Donors |
|---|---|---|---|---|---|
| CCL2 | MCP1 | NM_002982 | 3·13 | 8·70E-04 | 4/4 |
| TNF | TNF | NM_000594 | 2·56 | 1·63E-03 | 3/4 |
| CXCL10 | IP10 | NM_001565 | 2·44 | 1·44E-02 | 3/4 |
| CCL4L1 | MIP-1β | NM_002984 | 2·33 | 4·49E-04 | 4/4 |
| IL1RN | IL1-R Antagonist | NM_000577 | 2·13 | 1·49E-02 | 3/4 |
1
Gene expression levels were compared for natural killer (NK) cells cultured in IgG1-coated plates with or without soluble inducible T-cell co-stimulator (sICOS). Only genes that had a twofold increase or decrease with sICOS compared with IgG1 are listed here.
2
Only genes that were significantly modulated in at least three of four donors are shown.