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. Author manuscript; available in PMC: 2015 Sep 2.
Published in final edited form as: Mol Cancer Ther. 2014 Nov 5;14(1):90–100. doi: 10.1158/1535-7163.MCT-14-0496

Figure 2.

Figure 2

Validation of PP2A-C as a mediator of cisplatin cytotoxicity. A, Western blot showing stable knockdown of PP2A-C in OVCAR-8 cells. B, Cell viability (MTT) assay demonstrating increased sensitivity to cisplatin and LB100 following PP2A-C knockdown. C and D, Western Blot showing hyperphosphorylation of Chk1 (S345) for up to 8 hrs following cisplatin washout in PP2A-C knockdown (C) and LB100 treated (D) OVCAR-8 cells.