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. Author manuscript; available in PMC: 2015 Sep 2.
Published in final edited form as: Mol Cancer Ther. 2014 Nov 5;14(1):90–100. doi: 10.1158/1535-7163.MCT-14-0496

Figure 3.

Figure 3

Potential mechanisms of LB100 induced cisplatin sensitization in SKOV-3 cells. A, Western blot showing LB100 mediated regulation of DNA damage response proteins. B, Western blot of cell lysates collected after 24 h of treatment showing LB100-induced changes in the phosphorylation states of cell cycle related proteins. C, Western blot demonstrating differential generation of 14-3-3 p-Ser binding sites with LB100 alone or in combination with cisplatin. D, Simplified scheme highlighting potential mechanisms involved in LB100-induced cisplatin sensitization.