Table 2.
Cell cycle analysis of SKOV-3 and OVCAR8 cells
| SKOV-3 | OVCAR-8 | ||||||
|---|---|---|---|---|---|---|---|
| % G1 (SD) | % S (SD) | % G2/M (SD) | % G1 (SD) | % S (SD) | % G2/M (SD) | ||
| 24 Hour | |||||||
| Control (PBS) | 58.0 (0.9) | 21.1 (0.6) | 20.9 (0.8) | Control (PBS) | 39.8 (0.9) | 40.9 (0.5) | 19.3 (0.3) |
| LB100 (5 μM) | 51.4 (1.5) | 19.7 (0.8) | 28.9 (1.2) | LB100 (2 μM) | 45.4 (1.5) | 37.0 (1.6) | 17.6 (0.4) |
| Cisplatin (18 μM) | 49.8 (2.3) | 33.6 (1.8) | 16.6 (1.3) | Cisplatin (5 μM) | 4.6 (2.0) | 81.9 (1.6) | 13.4 (0.6) |
| Cisplatin (18 μM) + LB100 (5 μM) | 55.1 (1.2) | 26.6 (2.2) | 18.3 (2.9) | Cisplatin (5 μM) + LB100 (2 μM) | 18.5 (0.4) | 59.2 (1.0) | 22.3 (0.7) |
| 48 Hour | |||||||
| Control (PBS) | 58.0 (0.9) | 14.8 (0.5) | 19.4 (0.9) | Control (PBS) | 60.8 (0.9) | 28.0 (0.2) | 11.3 (0.3) |
| LB100 (5 μM) | 47.2 (1.9) | 30.2 (3.1) | 25.1 (0.8) | LB100 (2 μM) | 55.3 (0.4) | 29.9 (1.1) | 14.9 (1.5) |
| Cisplatin (18 μM) | 40.4 (0.8) | 38.4 (0.5) | 21.2 (1.0) | Cisplatin (5 μM) | 0.85 (0.3) | 20.7 (2.1) | 78.5 (2.2) |
| Cisplatin (18 μM) + LB100 (5 μM) | 50.4 (4.1) | 24.7 (1.6) | 25.0 (3.1) | Cisplatin (5 μM) + LB100 (2 μM) | 0.98 (0.2) | 32.6 (0.7) | 66.5 (0.5) |