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. Author manuscript; available in PMC: 2016 Sep 21.
Published in final edited form as: Analyst. 2015 Sep 21;140(18):6354–6362. doi: 10.1039/c5an01191d

Figure 6.

Figure 6

Optical response as a function of the concentration of methylated DNA target. The reported response (|ΔΔλ|) is the difference between the optical shift in the wavelength of peak diffraction upon hybridization of the methylated target and the detected shift upon hybridization of the PM target. The inset shows the raw response generated by hybridization of the mPM target. Samples were annealed from 85 to 55 °C utilizing a ramp rate of 0.2 °C/min and target DNA concentrations ranging from 100 to 500 µM. Diffraction measurements were taken in a 10 mM NaCl solution at pH 6 and at room temperature. Error bars represent ±1σ from the mean of 3–6 samples.