Table 1.
Treatment | Gastric secretion (Mean ± SEM) | Ulcer index (mm) Mean ± SEM | % of ulcer protection | ||
---|---|---|---|---|---|
Volume (ml) | pH | Acid output (Eq/100 g/4 h) | |||
Group 1 (5 ml distilled water/kg) | 2.114±0.13 | 2.80±0.01 | 2.80±0.01 | 2.850±0.07 | - |
Group 2 Indomethacin (25 mg/kg) | 9.280±0.09ααα | 1.07±0.01ααα | 24.47±2.28ααα | 39.12±0.81ααα | - |
Group3 MeOH PF (100 mg/kg) | 4.296±0.11*** | 2.51±0.02*** | 10.99±0.11*** | 10.57±0.15*** | 72.98 |
Group 4 MeOH PF (200 mg/kg) | 2.670±0.21*** | 2.71±0.71*** | 7.62±0.14*** | 8.38±0.05*** | 78.58 |
Group5 Ranitidine (10 mg/kg) | 2.426±0.52*** | 2.89±0.03*** | 5.30±0.31*** | 6.69±0.06*** | 82.89 |
MeOH PF= methanol extract of Paederia foetida; n=5; Data = Mean±SEM; ααα P<0.001 (G1 Vs G2); *** P<0.001, (Group 2 Vs Group 3, 4 & 5)