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. Author manuscript; available in PMC: 2016 Jul 16.
Published in final edited form as: Cell. 2015 Jul 2;162(2):314–327. doi: 10.1016/j.cell.2015.06.018

Figure 4. Capping domain.

Figure 4

(A) Structure of the capping domain. Residues 866–1334 in ribbon representation. Motifs GxxT and HR are sites of guanosine nucleotide binding and of covalent RNA attachment, respectively. Residues corresponding to positions of inhibitor-resistance mutations in human RSV polymerase (Liuzzi et al., 2005) are shown as red spheres.

(B) Close-up of the active site.

(C) Configuration of the priming loop in VSV-L. Only the RdRp and capping domains are shown. The priming loop (residues 1157–1173) protrudes from the capping domain into the active site of the RdRp domain.

(D) Proposed domain shifts to allow transcript elongation and eventual template release.