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. Author manuscript; available in PMC: 2015 Sep 2.
Published in final edited form as: Cell. 2010 Sep 17;142(6):844–846. doi: 10.1016/j.cell.2010.08.032

Figure 1. Readers Determine the Effects of Lysine Methylation.

Figure 1

The schematic depicts three different models for how methyllysine readers can sense and transduce histone methylation marks into biological outcomes.

(A) A specific reader recognizes one mark and links it to one specific outcome. In this way, distinct readers link different marks to alternate functional outcomes.

(B) Five distinct readers all specifically recognize the same mark, for example trimethylated histone H3 lysine 4 (H3K4me3), resulting in five alternate biological outputs being linked to the one mark.

(C) One reader binds to multiple different marks (such as H3K9me3, H3K27me3, and H4K20me3), linking the three different marks to a single biological output.