. Author manuscript; available in PMC: 2016 Jan 31.

Published in final edited form as: J Pharm Biomed Anal. 2014 Nov 18;104:55–61. doi: 10.1016/j.jpba.2014.11.011

Table 5.

Concentration of Rifamycin Antibiotics in Human Plasma Patient Derived Samples

Analyte	(n)	Oral Dose (mg)	Time (average hours post dose)	Conc. ng/mL (Median, IQR)
RIF	10	600	9.5	5,472 (981 – 6,587)
dRIF	5	-	9.5	1,070 (92.3 – 1,420)
RBT	24	150	10.8	232 (192 – 378)
dRBT	24	-	10.8	173 (84.0 – 232)
RPT	242	~10 mg/kg	13.8	11,471 (6,750 – 16,742)
dRPT	242	-	13.8	8,969 (5,337 – 14,925)

Rifabutin (RBT), desacetylrifabutin (dRBT), rifampin (RIF), desacetylrifampin (dRIF), rifapentine (RPT), desacetylrifapentine (dRPT).