Table 3.

Effect of prescribed dietary protein on change in measured GFR, creatinine and cystatin C independent of GFR, and estimated GFR using creatinine and cystatin C.^*

	Study A (n=302)		Study B (n=124)
ΔGFR (ml/min/1.73 m2)	−0.3	[−2.1, 1.6]	−0.2	[−1.9, 1.4]
Δ Serum Creatinine (mg/dl)	−0.22	[−0.36, −0.08]	−0.28	[−0.82, 0.21]
Δ eGFRcr (ml/min/1.73 m2)	+2.2	[0.6, 3.9]	+0.8	[−1.0, 2.6]
Δ Serum Cystatin C (mg/l)	0.02	[−0.08, 0.13]	0.10	[−0.15, 0.26]
Δ eGFRcys (ml/min/1.73 m2)	−0.4	[−2.1, 0.9]	−0.3	−1.5, 2.2]

^*Differences between randomized groups (change in low protein diet group minus change in usual protein diet group in Study A; very low minus low protein diet group).

Change is defined as 24 mo-baseline. Changes in creatinine and cystatin C and eGFR measurements are adjusted for change in measured GFR.

All values are reported as mean and 95% CI. Values highlighted in boldface font are statistically significant with p<0.01