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. 2015 Jul 25;16:53. doi: 10.1186/s12881-015-0203-0

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© Battini et al. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — a-d. Single voxel short TE (35 ms) 1H-MRS acquired from posterior centrum semiovale (WM) and interhemispheric parieto-occipital gray matter (GM) at 19 years (a-b). Single voxel short TE (35 ms) 1H MRS acquired from posterior centrum semiovale (WM) and interhemispheric parieto-occipital (GM) at 19 years (a - b); a comparison with the first 1H-MRS acquisition (7 years) was shown (c-d). In WM was present a decreased Choline (Cho) that is slightly reduced also in GM; no changes in proton MRS have been observed over the time