Table 1.
Metacore networks of significant genes
| MetaCore Networks | p-Value | Genes |
|---|---|---|
| Blood coagulation | 7.03E-05 | SERPINA6 (1.51), ADAMTS14 (−1.31), LMAN1 (−.24), MST1 (1.03), KRT18 (1.25), VWF (1) |
| KNG1 (1.74), F11 (1.69), TMPRSS6 (1.09) | ||
| WNT signaling | 2.63E-03 | ESR1 (1.40), TGFB3 (−1.22), WNT10B (1.47), WNT6 (1.74), FOXA2 (1.84), APC (−1.01), ADCY1 (1.29) |
| NFATC1 (−1), SFRP1 (2.47) | ||
| IL-2 signaling | 8.45E-03 | ESR1 (1.40), SYK (1.60), NFATC1 (−1), LCK (1.64), CCR2 (1.32), BCL2 (−1.02), TMPRSS6 (1.09), |
| Blood vessel morphogenesis | 1.03E-02 | PDE6B (1.56), NPR1 (1.47), TBX1 (1.43), TNNC1 (1.12), MMP19 (−1.15), VCAM1 (−1.46), |
| CEACAM6 (1.25), GRB7 (1.56), FOXF1 (2.40) | ||
| Ossification and bone remodeling | 1.73E-02 | IGFBP4 (1.12), TGFB3 (−1.22), CHRDL1 (−1.10), WNT6 (1.74), WNT10B (1.47), COL10A1 (−2.60), |
| TWIST1 (−1.06), RUNX2 (−1.03) | ||
| Connective tissue degradation | 1.93E-02 | LNPEP (−1.18), ADAMTS14 (−1.31), PCSK6 (2.56), CTSG (1.60), MMP19 (−1.15), TMPRSS6 (1.09), |
| Kallikrein-kinin system | 2.29E-02 | ADAMTS14 (−1.31), KNG1 (1.74), VWF (1.0), NOS2 (1.0), KNG1 (1.74), PTGES2 (1.09), F11 (1.69), |
| ECM remodeling | 2.46E-02 | ADAMTS14 (−1.31), PCSK6 (2.56), CSTG (1.60), MMP19 (−1.15), COL10A1 (−2.60) |
| Hedgehog signaling | 2.53E-02 | GAS1 (−1.30), TBX1 (1.43), FOXA2 (1.84), ADCY1 (1.29), JAG2 (1.60), BMI1 (−1.57), GLI1 (−1.49) |
| FOXF1 (2.40), EYA2 (−1.16), CDC37 (1.40), SOX8 (2.0), SOX3 (3.18) | ||
| Feeding and Neurohormone signaling | 2.66E-02 | TAC3 (1.25), KIT (1.64), TGFB3 (−1.22), ADCY1 (1.29), CCR2 (1.32), GLI1 (−1.49), BCL2 (−1.04) |
| Bile acids transport and its regulation | 2.70E-02 | SULT2A1 (2.25), ABCC4 (−1.02), ABCG5 (2.12), ABCB1 (1.51) |
| Muscle contraction | 3.26E-02 | THBS1 (−1.15), GUCA1B (1.25), KCNH2 (1.64), NPR1 (1.47), TNNC1 (1.12), GAL (1.64) |
| MYBPH (−1.41), GUCA1B (1.25) | ||
| Regulation of angiogenesis | 3.92E-02 | EFNA1 (1.0), IL1R1 (−1.18), THBS1 (−1.15), GLI1 (−1.49), CARD11 (1.47) |
| Neurogenesis | 4.17E-02 | CACNA1B (1.06), RIMS4 (1.36), PCP4 (1.09), SYT3 (1.32), THBS1 (−1.15), WNT6 (1.74) |
| WNT10B (1.47), POU4F1 (1.32), ERBB3 (1.03) | ||
| Visual perception | 4.45E-02 | PDE6B (1.56), GUCA1B (1.25), MYO7A (1.12), PRPH (1.15), RLBP1 (2.25) |
| Leucocyte chemotaxis | 4.53E-02 | LPAR2 (1.15), LIMK1 (−1.10), SKAP1 (2.40), VCAM1 (−1.47), CD2 (2.06), LCK (1.64) |
| CCL17 (1.22), CCR2 (1.32) |
The names of genes were shown, the values indicate the log2 (fold change) of Mastocytosis/Donor