Table 4.
TERT sequence variation and incident coronary heart disease. ARIC study (1987 – 2011)
| African-American (N = 3,022) (MI/Fatal CHD = 403) | White (N = 8,987) (MI/Fatal CHD =933) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Model 1 | Model 2 | Model 1 | Model 2 | |||||||||
| dbSNP ID | HRR | 95 % CI | p | HRR | 95 % CI | p | HRR | 95 % CI | p | HRR | 95 % CI | p |
| rs2736122* | ||||||||||||
| CHD | 1.20 | 1.03, 1.40 | 0.02 | 1.18 | 1.01, 1.39 | 0.04 | 0.95 | 0.86, 1.06 | 0.38 | 0.94 | 0.85, 1.05 | 0.29 |
| rs4246742* | ||||||||||||
| CHD | 1.00 | 0.87, 1.15 | 0.97 | 0.98 | 0.85, 1.14 | 0.83 | 0.96 | 0.85, 1.09 | 0.56 | 0.99 | 0.87, 1.13 | 0.88 |
| rs6863494 | ||||||||||||
| CHD | 0.93 | 0.67,1.29 | 0.66 | 0.95 | 0.68, 1.32 | 0.77 | -- | -- | ||||
| rs4975605 | ||||||||||||
| CHD | 1.04 | 0.91, 1.19 | 0.55 | 1.05 | 0.91, 1.20 | 0.52 | 1.02 | 0.94, 1.12 | 0.61 | 1.02 | 0.93, 1.11 | 0.74 |
| rs2736100 | ||||||||||||
| CHD | 0.99 | 0.86, 1.14 | 0.89 | 1.00 | 0.86, 1.15 | 0.97 | 0.97 | 0.88, 1.06 | 0.48 | 0.98 | 0.89, 1.07 | 0.60 |
| rs2853668 | ||||||||||||
| CHD | 0.93 | 0.81, 1.07 | 0.32 | 0.98 | 0.84, 1.13 | 0.73 | 1.05 | 0.95, 1.16 | 0.35 | 1.07 | 0.97, 1.19 | 0.19 |
dbSNP, The National Center for Biotechnology Information’s SNP database; SNP, single nucleotide polymorphism; ID, identification; N, number; HRR, hazard rate ratio; CI, confidence interval; p, p-value for hazard rate ratios from Cox regression models; MI, myocardial infarction; CHD, coronary heart disease; Model 1, adjusted for age and gender; Model 2, adjusted for age, gender, BMI, current smoking, diabetes, hypertension, HDL cholesterol, and LDL cholesterol; *not consistent with proportional hazards assumptions in whites for rs2736122 (Model 1) and rs4246742 (Models 1 and 2)