Table 6.

TERT sequence variation and all-cause mortality. ARIC study (1987 – 2011)

	African-American (N = 3,319) (Deaths = 1,203)						White (N = 9,827) (Deaths = 2,875)
	Model 1			Model 2			Model 1			Model 2
dbSNP ID	HRR	95 % CI	p	HRR	95 % CI	p	HRR	95 % CI	p	HRR	95 % CI	p
rs2736122
Mortality	1.05	0.95, 1.15	0.36	1.04	0.94, 1.14	0.47	1.04	0.98, 1.10	0.22	1.03	0.97, 1.10	0.27
rs4246742
Mortality	0.99	0.91, 1.08	0.85	0.99	0.90, 1.08	0.76	1.01	0.94, 1.08	0.80	1.02	0.95, 1.09	0.63
rs6863494
Mortality	1.00	0.84, 1.20	0.96	1.00	0.84, 1.20	0.96	--			--
rs4975605
Mortality	0.96	0.89, 1.04	0.37	0.94	0.87, 1.02	0.16	1.00	0.95, 1.05	0.96	0.99	0.94, 1.04	0.74
rs2736100
Mortality	1.00	0.92, 1.09	0.93	0.98	0.90, 1.07	0.73	1.03	0.98, 1.09	0.21	1.03	0.97, 1.08	0.32
rs2853668*
Mortality	1.00	0.92, 1.09	0.94	0.97	0.89, 1.05	0.44	0.99	0.93, 1.05	0.73	1.02	0.96, 1.08	0.62

dbSNP, The National Center for Biotechnology Information’s SNP database; SNP, single nucleotide polymorphism; ID, identification; N, number; HRR, hazard rate ratio; CI, confidence interval; p, p-value for hazard rate ratios from Cox regression models; Model 1, adjusted for age and gender; Model 2, adjusted for age, gender, BMI, current smoking, diabetes, hypertension, HDL cholesterol, LDL cholesterol; * not consistent with proportional hazards assumptions in whites for rs2853668 (Model 1)