Table 1. Classification of circulating Tfh-like cell subsets.
(CD45RO+CXCR5+ CD4+CD3+ cells) | PD1, ICOS, CCR7 expression | ||
---|---|---|---|
Tfh1-like (CXCR3+ CCR6-) | PD1++ ICOS+ CCR7low | PD1+ ICOS- CCR7int | PD1- ICOS- CCR7Hi |
Tfh2-like (CXCR3- CCR6-) | PD1++ ICOS+ CCR7low | PD1+ ICOS- CCR7int | PD1- ICOS- CCR7 Hi |
Tfh17-like (CXCR3- CCR6+) | PD1++ ICOS+ CCR7low | PD1+ ICOS- CCR7int | PD1- ICOS- CCR7 Hi |
This classification is based on the model proposed by Schmitt et al [19].