. 2015 Sep 2;10(9):e0137195. doi: 10.1371/journal.pone.0137195

Table 2. Correlational analyses between PD1⁺ICOS⁺ Tfh-like subsets and memory B cells.

	IgD^-CD38^HiCD27⁺ B cells
Gardasil	D7 (r/p) ^a	D14 (r/p)	D30 (r/p)	D2 post-third (r/p)	D7-post third (r/p)	M7 (r/p)
PD1⁺ ICOS⁺ Tfh1 at D7	(0.693 / 0.031)	NS ^b	(0.671 / 0.039)	NS	NS	NS
PD1⁺ ICOS⁺ Tfh2 at D7	NS	NS	(0.854 / 0.003)	NS	NS	NS
PD1⁺ ICOS⁺ Tfh17 ^c at D7	NS	NS	NS	NS	NS	NS
Cervarix	D7 (r/p)	D14 (r/p)	D30 (r/p)	D2 post-third (r/p)	D7-post third (r/p)	M7 (r/p)
PD1⁺ ICOS⁺ Tfh1 at D7	NS	NS	(0.862 / 0.008)	NS	NS	NS
PD1⁺ ICOS⁺ Tfh2 at D7	NS	NS	NS	NS	NS	NS
PD1⁺ ICOS⁺ Tfh17 at D7	NS	NS	NS	NS	NS	NS

Fold changes in different Tfh-like subsets (indicated as Tfh1, Tfh2, and Tfh17) at D7 over the pre-vaccinated time points were compared to the fold changes in the memory B cells at the indicated days (over the pre-vaccinated time points).

^a r indicates correlation coefficient from Spearman rank correlation analyses; p indicates p value from the Spearman correlational rank analyses.

^b NS, not significant.

^c The frequencies of Tfh17 subsets in some subjects were 0% at the baseline; therefore, we could not analyze some of the subjects. For the Tfh1 and 2 subsets, 10 subjects for Gardasil were compared, and it was 8 for Cervarix at D7, 14, and 30. For the other 3 time points, the numbers ranged 5–8 in both groups

Table 2. Correlational analyses between PD1+ICOS+ Tfh-like subsets and memory B cells.

Table 2. Correlational analyses between PD1⁺ICOS⁺ Tfh-like subsets and memory B cells.