Table 3. Univariate and multivariate Cox regression analyses of SPON2 protein expression and clinical variables for overall survival of CRC patients.
| Methods | Variables | β | SE (β) | Wald χ2 | p | Hazard ratio | 95% CI | |
|---|---|---|---|---|---|---|---|---|
| Low | Upper | |||||||
| Univariate Cox regression | ||||||||
| Gender | −.277 | .298 | .867 | .352 | .758 | .423 | 1.358 | |
| Age | .010 | .012 | .725 | .395 | 1.010 | .987 | 1.034 | |
| T stage | .847 | .311 | 7.405 | .007 | 2.332 | 1.267 | 4.291 | |
| N stage | .928 | .211 | 19.373 | .000 | 2.530 | 1.673 | 3.825 | |
| M stage | .697 | .724 | .926 | .336 | 2.007 | .486 | 8.290 | |
| Grade | .904 | .426 | 4.502 | .034 | 2.470 | 1.071 | 5.695 | |
| SPON2 expression | .620 | .184 | 11.425 | .001 | 1.860 | 1.298 | 2.665 | |
| Multivariate Cox regression | ||||||||
| N stage | .938 | .221 | 17.958 | .000 | 2.554 | 1.655 | 3.940 | |
| SPON2 expression | .580 | .183 | 10.096 | .001 | 1.786 | 1.249 | 2.555 | |
β, regression coefficient; SE, standard error; CI, confidence interval.