Skip to main content
. 2015 Mar 30;6(17):15137–15149. doi: 10.18632/oncotarget.3526

Figure 6. NEDD4 facilitates PTEN degradation in PMEPA1 depleted cells.

Figure 6

(A) Western blot assay shows that overexpression of NEDD4 decreases PTEN in VCaP cells at 24 and 72 hours post transfection. (B) Inhibition of PMEPA1 by siRNA upregulates NEDD4 and AR, and results in decreases in PTEN protein levels in VCaP cells. (C) Simultaneous knockdown of PMEPA1 and PTEN leads to elevated AR and PSA levels and (D) enhanced cell growth (p < 0.01). (E) Model depicting three major consequences of PMEPA1 depletion in CaP cells such as increased cell growth, resistances to AR inhibitors and decrease PTEN protein level.