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. 2015 May 8;6(17):15164–15179. doi: 10.18632/oncotarget.3897

Figure 5. Modulating tumor-derived MMP3 levels alters CMS4-met.sel tumor growth.

Figure 5

A. Comparison of basal MMP3 expression between CMS4 and CMS4.met.sel at RNA (qPCR, left panel) or protein (ELISA, right panel) levels. B. Knockdown of MMP3 in CMS4.met.sel cells compared to the SC population as shown at RNA (qPCR, left panel) or protein (ELISA, right panel) levels. C. Tumor growth in wild-type mice (n = 18 per tumor cell line; left) or SCID mice (n = 5 per tumor cell line; right). D. Experimental lung metastases as shown by H&E-stained lung tissue sections (left), followed by quantification of approximate volume of lung occupied by tumor (right). Arrows indicate examples of lung tumor nodules. E. MMP3 levels in tumor explants at different time points post-implantation, as measured by qPCR. *P < 0.05 (experimental replicates).