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. 2015 May 8;6(17):15164–15179. doi: 10.18632/oncotarget.3897

Figure 6. Modulating tumor-derived MMP3 levels alters 4T1 tumor growth.

Figure 6

A. Endogenous MMP3 production levels in 4T1 cells compared to CMS4.met.sel cells, as shown by ELISA. B. Knockdown of MMP3 in 4T1 cells compared to SC population as shown at RNA (qPCR, left panel) or protein (ELISA, right panel) levels. C. Tumor growth in wild-type mice (n = 18 for each tumor cell line). D. Experimental lung metastases as shown by H&E-stained lung tissue sections (upper) followed by histologic quantification of tumor nodules (lower). Arrows indicate examples of lung tumor nodules (n = 4 per group). *P < 0.05.